Research

From G Papadantonakis

My research interests lie in the field of experimental and computational biophysical chemistry. My investigations are focused on cancer biology. I investigate photosensors as model systems for signal transduction and protein function and I work towards understanding the mechanisms of DNA damage by environmental contaminants, reactive chemical species and photoionization.

Selected Publications

1. G.A. Papadantonakis,H. Fernando, N.S. Kim, P. R. LeBreton, In Molecular Modeling of Nucleic Acids; ACS Symposium Series 682; Leontis N., SantaLucia J., Jr., Eds.; American Chemical Society, Washington, D.C., 1997; p.p. 18-40. The Energetics of Nucleotide Ionization in Water-Counterion Environments.

2. Conduction-Band-Edge Ionization Thresholds for DNA Components In Aqueous Solutions; G. A. Papadantonakis, H. Fernando, N.S. Kim, P. R. LeBreton, Proc. Natl. Acad. Sci. USA, 1998, 95, 5550-5555.

3. Nanosecond UV Laser Photoionization of Aqueous Tryptophan: Temperature Dependence of Quantum Yield, Mechanism, and Kinetics of Hydrated Electron Decay; K. L. Stevenson, P. R. LeBreton, G. A. Papadantonakis, J. Photochem. Photobiol., A: Chem, 2000, 133(3), 159-167.

4.Evidence of Temperature Dependent Activation Barriers for Near-Threshold Aqueous Photoionization of 2’-Deoxyguanosine and Tryptophan; G. A. Papadantonakis, K. L. Stevenson, P. R. LeBreton, Chem. Phys. Lett. 2001, 346, 97-102.

5. Low-Energy, Low-Yield Photoionization and Production of 8’-Oxo-2’-deoxyguanosine and Guanine from 2’-Deoxyguanosine, R. S. Tranter, Y. Yang, K. Brezinsky, R. B. van Breemen, P. R. LeBreton, G. A. Papadantonakis , J. Phys. Chem. B 2002, 106, 7704-7712

6. Functional Tuning of Photoactive Yellow Protein by Active Stte 46, A.F. Philip, K.T. Eisenman, G. A. Papadantonakis, W. D. Hoff Biochemistry 2008, 47, 13800-13810

7. Spectral Tuning in Photoactive Yellow Protein by Modulation of the Shape of the Excited State Energy Surface,A.F. Philip, R. A. Norme, G. A. Papadantonakis,N. F. Scherer, W. D. Hoff, Proc. Natl. Acad. Sci. USA, 2010, 107, 5821-5826